Shafi Ali Alsharari
General Practitioner, Resident of Emergency Department, AlQurayyat General Hospital, Saudi Arabia
Publications
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Research Article
UPDATES ON MANAGEMENT OF REFRACTORY/ RELAPSED MULTIPLE MYELOMA AND ITS ASSOCIATED ANXIETY AND DEPRESSION: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS
Author(s): Ibrahim Abdelkhalek Ibrahim*, Reef Faris Ismail Alsabilah, Raghad Faris Ismail Alsabilah, Haya Khaled Saud Altarif, Hadeel Abdulrahman Aljoufi, Shahad Fayez Hassan Albalawi and Shafi Ali Alsharari
Objectives: To study the recently published randomized control trials (RCTs) on the management of relapsed/ refractory multiple myeloma (RRMM). Methods: We conducted a thorough search of PubMed, SCOPUS, Web of Science, and Google Scholar to find pertinent literature. Rayyan QRCI was utilized during the entire process. Results: We included seven studies with a total of 1578 children and 953 (60.4%) were males. The follow-up duration ranged from 7.1 to 65.4 months. One study used mAb alone and reported that this line of treatment is fast, of high quality, and with a good safety profile. Another study used mAb (Daratumumab) along with an bortezomib and dexamethasone and reported that this combination showed significant efficacy advantages regarding PFS, OS, and depth of response. PFS, OS, and depth of response also we.. Read More»